Endocrine Abstracts

Background: Bloom’s syndrome is a rare autosomal recessive disorder due to chromosomal instability. It is associated with endocrinopathies such as growth deficiency, insulin resistance, type 2 diabetes, dyslipidemia and hypothyroidism. We present a case to highlight the challenges in management of diabetic emergencies in patients with complex syndromes.Case report: A 38-year-old male of Asian descent known to have Bloom’s syndrome presented to ...

Background: Knowledge of glucocorticoid use during acute illness is widely known, however, knowledge of Diabetes Insipidus (DI) is suboptimal amongst healthcare professionals. In 2009, a series of medical and management failures led to the death of 22 year old from DI in a London hospital. Since then increased efforts have been made to raise awareness about the inpatient management of DI and dangers associated with delay and/or omission of desmopressin. An NHS England patient ...

Case: An 89 year old gentleman was admitted to hospital following a collapse at home. His capillary blood glucose was found to be 1.4 mmol/l by the paramedics. The patient had experienced multiple collapses at home in the preceding 2 weeks. Each time, he had been found to be hypoglycaemic but treated and discharged from A&E. He complained of reduced appetite, weight loss and change in bowel habit. The patient’s past medical history included a large fibroma of the left...

Background: The Covid-19 pandemic has led to various unprecedented challenges and obstacles, especially in the field of Diabetes and Metabolism, many of which are as novel as the pandemic itself. Discovering efficacious therapeutic options resulting in positive outcomes has been a challenge. Dexamethasone has been shown to reduce mortality in patients with Covid-19 pneumonitis who require oxygen therapy and/or ventilation. Exogenous steroid therapy is renowned to cause adverse...

Background: The prevalence rate of Diabetes within Manchester is higher than the national average of England. Association of British Clinical Diabetologists (ABCD) guidance highlights an increased risk of typical and atypical presentations of diabetic emergencies in patients with Diabetes and COVID-19. In the absence of early recognition and treatment, this could lead to adverse outcomes and poor prognosis, thus leading to increased mortality rates.Aims:...

: A 26 year old 22 weeks pregnant woman was referred to the Endocrine team after she presented with high blood pressure without evidence of proteinuria. She had no past medical history and was newly diagnosed with gestational diabetes. On clinical examination, she had some clinical features consistent with hypercortisolism such as very prominent large purplish striae over her abdomen, bad facial acne, multiple superficial ecchymoses due to easy skin bruisability and excessive ...

Case History: A 46 year old lady presented to A&E with a 4 day history of headache, vomiting, abdominal pain and fever. On further questioning, she admitted to having had experienced occasional episodes of palpitations, hot flushes and headaches over the past few months. She had history of appendectomy when she was young and acoustic neuroma removal few years ago. She wasn’t on any regular medications. On clinical examination, she looked visibly unwell and was hypoxic...

Background: Genetic causes of hypocalcaemia can be overlooked in patients presenting without apparent syndromic features. One such example is DiGeorge syndrome, which is often diagnosed in childhood but rarely in adulthood.Case presentation: A 21-year-old lady was referred to our endocrinology clinic regarding chronic hypocalcaemia (adjusted calcium 1.98 mmol/l). This was first diagnosed at the age of eight with no clear cause identified. Her past medica...

Aim: To assess the appropriateness of parathyroid imaging performed in patients with primary hyperparathyroidism at the United Lincolnshire Hospital NHS Trust from 2018 to 2019.Background: Primary hyperparathyroidism (PHPT) is a clinical and biochemical diagnosis. Reported sensitivity for imaging localisation of parathyroid adenomas for ultrasound and sestamibi scans are not high at 65 to 85% and 71 to 92%, respectively. Surgeons use combined ultrasound ...

Background: Ectopic Cushing’s syndrome (ECS) is a rare and severe condition at times presenting acutely with intense hypercortisolism. The intensity of hypercortisolism can be disproportionate to underlying tumoral condition, and associated life-threatening complications are common arising suddenly. Hypercortisolism must be controlled rapidly pending definitive treatment of tumoral source to avoid life-threatening consequences.Case Summary: 31-year-...